Synthesis and Some Reactions of 4-Benzoyl-5-Phenyl-1-(2,4,6-Trichloro Phenyl)-1H-Pyrazole-3-Carboxylic Acid

It has long been known that pyrazole and fused pyrazole compounds possess numerous chemical, biological, medicinal and agricultural applications because of their versatile biological activities appearing as antimicrobial, antiviral, antitumor, anti-inflammatory, antihistaminic, pesticidal, antifungal and antipyretic agents. On the other hand, cyclic oxalyl compounds of type 1 have been used successfully as starting materials to synthesize various 1,4,5-trisubstitute pyrazol-3-carboxylic acids and their derivatives via reactions of them with various hydrazines or hydrazones for some 2 decades9−11. Here, we report the chemical behavior of furandione 1 toward a different arylhydrazine compound, the orthopositions of which are occupied by chlorine atoms, and present the reactions of cyclic oxalyl compounds with various hydrazines or hydrazones to prepare new pyrazole and pyridazine derivatives.